Über 7 Millionen englischsprachige Bücher. Jetzt versandkostenfrei bestellen The treatment of vitiligo needs to be individualized and thus a tentative plan of management should be decided at the very outset and a realistic goal should be set. The management of vitiligo begins with a through clinical assessment, which becomes very important in the context of inconclusive investigational parameters Medical therapy is considered as the first line of management in this age group. All children with widespread vitiligo should undertake photoprotection preferably with opaque sunscreens during daytime outdoor activities. In general, localized vitiligo is treated with topical therapy
Dexamethasone 10 mg divided in 2 days as pulse therapy in adults has been reported to stop rapidly progressive vitiligo, causing less severe side effects compared to the continuous regimen. Topical immunomodulators (TIMS), act both on inflammatory and differentiation processes In general, topical monotherapy is indicated for mild-to-moderate vitiligo. Current treatment options for vitiligo include medical, surgical and adjunctive treatments., Medical treatment targets the immune system and helps to arrest the spread of depigmentation In light of these limitations of medical treatment, surgical treatment of vitiligo was first proposed in the 1960s. Over the years, the concept of surgical treatment has been expanded to include surgical biotherapies such as autologous, cultured melanocyte transplantation Excellent response-Disappearance of vitiligo patch. Any side effect observed during treatment was also noted. Results. Total 166 cases of contact vitiligo were included but only 50 cases could complete 6 month follow up. This included 4 males and 46 females, with age between 14 to 60 years The outcome of treatment in 120 cases of vitiligo receiving psoralen was analyzed. Forty patients were treated with topical psoralen, another 40 patients were given oral psoralen and the remaining 40 patients used, both oral and topical psoralens. Treatment was given once daily followed by sun exposure for 6 months
Background: Vitiligo affects about 1% of the world's population, however, there is currently no universally used standardized measure to assess its response to treatment. Objective: To find the most effective technique for the quantitative assessment of therapeutic results in vitiligo patients. Materials and methods: The study was performed in three stages: (1) Conducting an adapted Delphi. 139 patients with vitiligo of long duration were treated with oral 8-MOP and UVA. 22 patients had focal and 117 generalized vitiligo. 27 had vitiligo on the skin of their face and/or neck and 58 on their hands and/or feet. Vitiligo of the face and/or neck responded very well to the treatment, 14 of
The goal of vitiligo treatment is to obtain skin repigmentation in the majority of cases, and less commonly to depigment the remaining normal skin. There is no consistent, long-term, durable therapy for vitiligo for all patients, highlighting the unmet need for new safe and effective therapies to control this disease . Microneedling is a safe and efficient technique in the treatment of vitiligo The strongest evidence of JAK-inhibitor efficacy was established for treatment of psoriasis. Additionally, data are available on the potential efficacy of JAK-inhibitors in alopecia areata, atopic dermatitis and vitiligo. Mostly, JAK-inhibitors are used orally Patients with an active, progressive vitiligo are treated with immunosuppressive therapies, such as, oral steroids. Oral steroids, in minipulse form, is a popular mode of therapy in India. Besides, oral levamisole and minocycline too have been used by clinicians, but these therapies carry their own risks
1. Indian J Dermatol Venereol Leprol. 2019 Sep-Oct;85(5):528-531. doi: 10.4103/ijdvl.IJDVL_656_18. Cyclosporine in treatment of progressive vitiligo: An open-label, single-arm interventional study 1. Indian J Dermatol Venereol Leprol. 2019 Sep-Oct;85(5):466-474. doi: 10.4103/ijdvl.IJDVL_63_17. Clinimetric analysis of recently applied quantitative tools in evaluation of vitiligo treatment The two most frequently used modalities in the treatment of vitiligo are PUVA and topical corticosteroids. In actively spreading vitiligo, PUVA therapy is not an ideal treatment First-line vitiligo treatment includes moderate-to-high strength topical corticosteroids and calcineurin inhibitors, both of which dampen the cellular immune response (Table 1, Table 1 Part 2)
Treatment options that have been used with NB-UVB in vitiligo till date include topical tacrolimus, 14,15 pimecrolimus, 16 Vitamin D analogues 17,18 and even topical pseudocatalase. 19 While some studies have shown a synergistic effect with these combinations, others have found the efficacy of the combinations to be similar to NB-UVB alone Vitiligo is a common pigmentation disorder in which the pigment cells ( melanocytes) are destroyed by an autoimmune process. The result is the appearance of slowly increasing white patches, without any change in the skin texture. The white patches of skin are prone to sunburn
Cyclosporine in treatment of progressive vitiligo: An open-label, single-arm interventional study. Indian J Dermatol Venereol Leprol. Sep-Oct 2019;85 (5):528-531. doi: 10.4103/ijdvl.IJDVL_656_18 Background: Vitiligo is a disorder caused by the loss of the melanocyte activity on melanin pigment generation. Studies show that oxidative-stress induced apoptosis in melanocytes is closely related to the pathogenesis of vitiligo. Glutamine is a well known antioxidant with anti-apoptotic effects, and is used in a variety of diseases 5-Fluorouracil (5-FU) is a cytotoxic agent that has been used systemically, topically and intralesionally for the treatment of many malignant and pre-malignant conditions. Topical chemotherapy with 5% 5-FU cream has been used as a standard treatment of actinic keratosis, superficial basal cell carcinomas and Bowen′s disease INTRODUCTION. Vitiligo is a chronic autoimmune disease that results from the destruction of melanocytes, causing white spots on the skin. Vitiligo affects approximately 1% of people worldwide and can affect both adults and children, causing diminished quality of life and marked psychological distress. 1-4 Treatments include topical corticosteroids and calcineurin inhibitors, but the most. Of the topical medications for vitiligo, corticosteroids were found in majority (75.5%) of the prescriptions followed by sun screen lotion (24.5%). On the other hand, oral vitamin E was the majorly prescribed systemic medication (43.3%) followed by multivitamin (27.8%), prednisolone (23.3%), and vitamin B complex (5.6%)
Role of Tofacitinib in the treatment of vitiligo Lubna Khondker, MD Associate Professor, Dept of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh ABSTRACT Background: Vitiligo is a condition of depigmentation of skin that often causes significant psychological distress for patients Vitiligo Treatment Oral Psoralens Photo chemotherapy - For those patients, more than 20 percent of whose body has been affected by Vitiligo, Oral PUVA can be an effective method of treatment. The Psorlen is generally taken orally just a couple of hours before exposing the body to Ultra Violet-A rays
However, the umbrella term 'vitiligo' can be applied to all forms of vitiligo except segmental vitiligo.(2) This holds truer for response to surgical treatments.(3) It is appropriate to compare the results for segmental and non-segmental vitiligo separately.(4) A study reported 53% versus 91% of patients with non-segmental and segmental. What you have is much more likely to be a mild fungus called tinea versicolor than vitiligo, drug-induced or otherwise. There's no useful treatment for vitiligo anyway, whereas fungus is easy to clear up. For definitive diagnosis and treatment, I suggest you consult a demratologist. Best. Dr. Rockoff. peacetoall Jul 04, 2010 In subgroup analysis, the risk of vitiligo was higher in female patients treated with anti-TNF therapy (HR = 2.46, 95% CI = 0.92−6.62) than in male patients (HR = 1.78, 95% CI = 0.78−4.05), although statistical significances were not shown in both groups ().Within the anti-TNF group, a markedly increased risk of vitiligo was observed in patients under 40 years of age (HR = 3.76, 95% CI = 1.
Childhood Vitiligo. IJDVL. 78(1):30-41. Patel NS, Paghdal KV, GF, 2012. Advanced Treatment Modalities for Vitiligo. Dermatol Surg, 38: 381-391. Ma C, Li Q, Li C, Gao T, 2013. Comparison of the 308 nm excimer laser with the 308 nm excimer lamp in the treatment of vitiligo - a randomized bilateral comparison study. Photodermatol Photoimunol. Vitiligo universalis is the most uncommon form of vitiligo and is probably the extreme severity end of the spectrum of nonsegmental vitiligo. Associated autoimmune phenomena seem more common; patients have to be followed up, as associated diseases may manifest months or years after being diagnosed vitiligo universalis vitiligo, 5-fluorouracil application after needling is a cost-effective, safe, and easy method of treatment with minimal Figure 1: Repigmentation in a small vitiligo patch on the wrist in a male patient after 2 months of treatment with 5-fluorouracil Figure 2: Repigmentation in vitiligo patch over face in a gir The treatment for vitiligo is primarily concerned with minimizing the appearance of white spots by restoring the skin color. Your GP will take into account your age, overall health, the extent of discoloration, and the area of the skin affected before recommending a viable treatment option for your case
Development of melanocye-keratinocyte co-culture model for controls and vitiligo to assess regulators of pigmentation and melanocytes. Indian journal of dermatology, venereology and leprology, 2012. Deepak Kaul. Download PDF. Download Full PDF Package. This paper. A short summary of this paper Segmental vitiligo. Segmental vitiligo is a subtype of vitiligo characterized by depigmented macules or patches arranged in a patterned distribution that is refractory to medical treatment but excellent response to surgical treatment 1).. Vitiligo is an acquired disorder characterized by depigmented macules or patches on the skin due to the loss of functional melanocytes Several treatment options are available for vitiligo, and they work to restore skin color or even out a person's skin tone. The success of these treatments varies from one person to another. Additionally, some treatments have serious adverse effects; which is why your doctor may first recommend trying improving the appearance of the skin with.
Methods: A total of 66 skin specimens from 33 volunteers with vitiligo were analyzed by immunohistochemistry using anti-CCN3 antibodies. Absence of topical or systemic treatment for vitiligo over the previous 30 days and availability of an area of non-lesional skin for biopsy at least 15 cm away from any vitiliginous macules were the main. Treatment of vitiligo with broadband ultraviolet B and vitamins. Don P, Iuga A, Dacko A, Hardick K Int J Dermatol 2006 Jan;45(1):63-5. doi: 10.1111/j.1365-4632.2005.02447.x. PMID: 1642638 The therapeutic goal in vitiligo is to improve the appearance of the affected skin, and this can be approached in different ways, which depend on the type of vitiligo, extent of disease, and wishes of the patient. Regardless of the chosen treatment, an assessment of the patient's perspective should be included as part of the evaluation