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Goodpasture syndrome

Goodpasture syndrome is a group of acute illnesses that affects the lungs and kidneys. It involves an autoimmune disorder. Normally, the immune system makes antibodies to fight off germs. But with Goodpasture syndrome, the immune system mistakenly makes antibodies that attack the lungs and kidneys

Goodpasture syndrome is an autoimmune disease that affects the lungs and kidneys and is characterized by pulmonary alveolar hemorrhage (bleeding in the lungs) and a kidney disease known as glomerulonephritis Anti-GBM disease is sometimes also called Goodpasture's disease. 1 Another related term is Goodpasture syndrome, a condition that also affects the kidneys and lungs but is not caused by anti-GBM antibodies. How common is anti-GBM disease? Anti-GBM disease is rare, with only about 1 in 1 million new cases being reported per year. Goodpasture's Syndrome is an uncommon autoimmune disease that affects both the kidneys and the lungs. An autoimmune disease means that the immune system, which usually protects the body from infection, attacks healthy parts of the body by mistake. What causes the disease

Goodpasture syndrome (GPS), also known as anti-glomerular basement membrane disease, is a rare autoimmune disease in which antibodies attack the basement membrane in lungs and kidneys, leading to bleeding from the lungs, glomerulonephritis, and kidney failure Goodpasture syndrome is a potentially fatal pulmonary-renal syndrome. One indicator of this condition is the presence of anti-glomerular basement membrane (GBM) antibodies. Another indicator is bleeding in the lungs Goodpasture syndrome is a rare but serious autoimmune disease that attacks the lungs and kidneys. The disease occurs when the body's immune system mistakenly produces antibodies against collagen in.. Goodpasture syndrome is a rare autoimmune disorder characterized by inflammation of the filtering structures (glomeruli) of the kidneys (glomerulonephritis) and excessive bleeding into the lungs (pulmonary hemorrhaging) Goodpasture syndrome is the combination of glomerulonephritis with alveolar hemorrhage and anti-GBM antibodies. Goodpasture syndrome most often manifests as diffuse alveolar hemorrhage and glomerulonephritis together but can occasionally cause glomerulonephritis (10 to 20%) or pulmonary disease (10%) alone. Men are affected more often than women

Goodpasture Syndrome Johns Hopkins Medicin

Goodpasture syndrome is a rare and potentially life-threatening autoimmune disease. It causes buildup of autoimmune proteins in the kidneys and lungs that leads to damage of these organs. The.. Anti-glomerular basement membrane diseases (anti-GBM diseases) is a rare disorder that can involve quickly worsening kidney failure and lung disease. Some forms of the disease involve just the lung or the kidney. Anti-GBM disease used to be known as Goodpasture syndrome Goodpasture syndrome is a rare autoimmune disorder that affects both the lungs and kidneys. The immune system typically makes antibodies to fight off infection. But with Goodpasture syndrome, the immune system mistakenly makes antibodies that attack the lungs and kidneys

Goodpasture syndrome Genetic and Rare Diseases

Goodpasture syndrome is a group of conditions that affects the kidneys and the lungs. It includes glomerulonephritis, bleeding in the lungs, and a problem with your immune system that causes it to attack the tiny filters in your kidneys and the tissue in your lungs. The damage to your kidneys can lead to chronic kidney disease and kidney failure Goodpasture's syndrome (GS) is a rare and organ-specific autoimmune disease that is mediated by anti-glomerular basement membrane (anti-GBM) antibodies and has pathology characterized by crescentic glomerulonephritis with linear immunofluorescent staining for IgG on the GBM. It typically presents as

Anti-GBM (Goodpasture's) Disease NIDD

Goodpasture's syndrome. A rare immunological lung disorder that can mimic pneumonia, Goodpasture's syndrome causes bleeding in your lungs as well as glomerulonephritis Goodpasture's syndrome (GS) is an autoimmune disorder that affects the lungs and the kidneys. It is caused by circulating anti-glomerular basement membrane (anti-GBM) antibodies that bind to the vascular basement membrane in the lung and kidneys, resulting in an autoimmune reaction Anti-glomerular basement membrane diseases (anti-GBM diseases) is a rare disorder that can involve quickly worsening kidney failure and lung disease. Some forms of the disease involve just the lung or the kidney. Anti-GBM disease used to be known as Goodpasture syndrome. The renal arteries supply the kidneys with blood

Goodpasture's Syndrome National Kidney Foundatio

  1. Goodpasture syndrome is an eponym that has been used to describe the clinical entity of diffuse pulmonary hemorrhage (as seen in the images below) and acute or rapidly progressive glomerulonephritis. Goodpasture disease is a term used to describe glomerulonephritis, with or without pulmonary hemorrhage, and the presence of circulating anti-gl..
  2. Goodpasture syndrome is an autoimmune disorder that typically causes kidney damage and diffuse alveolar hemorrhage (the pulmonary-renal syndrome ). Occasionally Goodpasture syndrome affects only the kidneys or only the lungs. Goodpasture syndrome usually affects young men. Some people appear to be genetically susceptible
  3. Goodpasture's disease, also known as anti-glomerular basement membrane antibody (anti-GBM) disease, is an important cause of pulmonary-renal syndrome (Goodpasture's syndrome). Pulmonary-renal syndrome consists of glomerulonephritis and pulmonary haemorrhage

Goodpasture's syndrome is a rare rapidly progressive and potentially fatal autoimmune condition mediated by anti-GBM antibodies, which are targeted against the α3 chain of type IV collagen (McAdoo and Pusey, 2017). The α3 chain is inclusively expressed in the basement membrane of the kidneys and lungs Goodpasture's syndrome is a rare condition that causes the body's immune system to attack healthy lung and kidney tissue. In some cases, a person will cough up blood and notice discomfort while urinating. Bleeding in the lungs is extremely dangerous, but with proper treatment the lungs can recover with little damage

Goodpasture syndrome - Wikipedi

  1. Goodpasture's Syndrome Images. It is a very rare autoimmune disorder that causes the antibodies to attack the kidneys and lungs that ultimately lead to kidney failure and lung hemorrhage. This may permanently damage the kidneys and lungs, which may even result in the death of an individual. The kidney damage sometimes leads to Glomerulonephritis
  2. The Goodpasture syndrome is an extremely rare disease, with renal and pulmonary manifestations, and is mediated by anti-glomerular basement membrane (anti-GBM) antibodies. Renal pathological changes are mainly characterized by glomerular crescent formation and linear immunofluorescent staining for immunoglobulin G on the GBM
  3. Goodpasture SyndromeInstructional Tutorial VideoCanadaQBank.comQBanks for AMC Exams, MCCEE, MCCQE & USMLEURL: http://youtu.be/S2Iotn0Hye
  4. Goodpasture syndrome can occur in people of any age. The first peak of morbidity is noted at the age of 20-30 years, with men suffering mainly from both renal and pulmonary lesions. The second wave of morbidity falls on the age of over 50-60 years, and men and women get sick with the same frequency

Goodpasture Syndrome (Anti-GBM Disease): What It is

Goodpasture syndrome is a rare autoimmune disorder that affects both the lungs and kidneys. The immune system typically makes antibodies to fight off infection. But with Goodpasture syndrome, the immune system mistakenly makes antibodies that attack the lungs and kidneys. This condition can quickly progress to an inflammation of the kidneys. Goodpasture Syndrome is a very rare autoimmune disease thataffects the lungs and or kidneys.•. In Goodpasture Syndrome, the immune system makesantibodies that attacks the kidneys and lungs.•. In a healthy immune system, antibodies are made to attackdiseases and viruses, in Goodpasture Syndrome it attacksvaluable body parts Goodpasture syndrome were not available at that time, so it is not known whether the patient had true Goodpasture syndrome or vasculitis. Vasculitis is an autoimmune condition—a disorder in which the body's immune system attacks the body's own cells and organs—that involves inlammation in the blood vessels and can cause similar lun Goodpasture syndrome is a rare autoimmune disease in which the body's immune system erroneously attacks its own tissues. Normally, your body makes antibodies (proteins that signal the immune system to attack) to fight infections. Goodpasture syndrome is characterized by antibodies that target specific proteins found in the lungs and kidneys What is Anti-Glomerular Basement Membrane Disease (also known as Goodpasture's Syndrome)? Anti-Glomerular Basement Membrane disease (anti-GBM disease) is a disease that occurs as a result of injury to small blood vessels (capillaries) in the kidneys and/or lungs. Autoantibodies are antibodies directed toward the body itself (rather than towards something foreign such as bacteria or viruses.

Goodpasture syndrome (anti-GBM disease) is a type II hypersensitivity reaction where autoantibodies are made against the glomerular basement membrane (GBM) and the alveolar basement membrane (Collagen IV specifically is targeted) The term Goodpasture disease has persisted, however, being generally reserved for patients with demonstrable anti-GBM antibodies, whereas Goodpasture syndrome may be used to describe copresentation with GN and pulmonary hemorrhage of any cause Bolton WK. Goodpasture's syndrome. Kidney Int 1996; 50:1753. Jayne DR, Marshall PD, Jones SJ, Lockwood CM. Autoantibodies to GBM and neutrophil cytoplasm in rapidly progressive glomerulonephritis. Kidney Int 1990; 37:965

Goodpasture Syndrome Overview: Diagnosis, Symptoms, and

  1. Goodpasture syndrome . type II hypersensitivity ; anti-GBM antibodies against α3-chain of collagen type IV . antibodies to the alveolar basement membrane result in hemoptysis and lung disease ; Pauci-immune processes. granulomatosis with polyangiitis ; microscopic polyangiitis; Light microscopy and immunofluorescenc
  2. Welcome to Goodpasture Christian School. For over 50 years, Goodpasture Christian School has been providing a stellar college-prepatory education in a Christian environment for students 12 months to 12th grade. Goodpasture has a long history of award-winning fine arts. Our faculty believes the arts promotes confidence in our young performers
  3. Goodpasture syndrome and Goodpasture disease are older terms often used synonymously to refer to anti-GBM antibody-mediated disease but also to the clinical constellation of glomerulonephritis and pulmonary hemorrhage, regardless of the underlying pathogenesis
  4. Goodpasture syndrome is an autoimmune disease of lung and kidney. Viral and streptococcal infections and exposure to hydrocarbon fumes have been suggested as possible causes. Three familial instances ( Gossain et al., 1972 ; Maddock et al., 1967 ), including a pair of identical twins ( D'Apice et al., 1978 ), have been reported
  5. Anti-GBM/Goodpasture's syndrome is a rare, but serious autoimmune disease that causes inflammation of the kidneys and lungs. In this syndrome, the immune system mistakenly makes anti-GBM antibodies which attack the lungs and kidneys, causing bleeding within the organs
  6. Goodpasture syndrome (GPS) also known as Goodpasture's disease is a rare autoimmune disease in which antibodies attack the basement membrane in lungs and kidneys, leading to bleeding from the lungs and to kidney failure Some forms of the disease involve just the lung or the kidney, most times, both

Goodpasture Syndrome - NORD (National Organization for

Goodpasture Syndrome - Pulmonary Disorders - Merck Manuals

Goodpasture Syndrome: Symptoms, Diagnosis, and Treatmen

Goodpasture syndrome is a rare autoimmune disease that affects the lungs and kidneys. Normally, the immune system makes antibodies to fight off germs. With Goodpasture syndrome, however, the immune system mistakenly makes antibodies that attack the lungs and kidneys. This condition can quickly progress to glomerulonephritis and kidney failure Goodpasture syndrome is an autoimmune condition that affects the kidneys and the lungs.In a normal person, antibodies are produced to fight against anything foreign like an infection

Approximate Synonyms. Goodpasture's syndrome; Goodpastures syndrome; Clinical Information. An autoimmune disease of the kidney and the lung. It is characterized by the presence of circulating autoantibodies targeting the epitopes in the non-collagenous domains of collagen type iv in the basement membranes of kidney glomeruli (kidney glomerulus) and lung alveoli (pulmonary alveoli), and the. Goodpasture Syndrome is an autoimmune disease with a specific etiopathogenesis and is characterized by both pulmonary and renal pathology. Goodpasture Syndrome is fundamentally initiated by the development of auto-antibodies to pulmonary and renal basement membrane antigens. Consequently, goodpasture syndrome can be considered a Type II. Goodpasture syndrome is a rare but severe autoimmune disease that strikes our lungs and kidneys. Goodpasture syndrome is a disease.. Prognosis. Goodpasture syndrome is a very rare and potentially life-threatening autoimmune disease that damages both the lungs and the kidneys. 1  It is also sometimes known as Goodpasture disease or anti-glomerular basement membrane (anti-GBM) disease. However, medical professionals sometimes use these terms slightly differently

Goodpasture Syndrome - Symptoms and Cause

Goodpasture syndrome (GPS), also known as anti-glomerular basement membrane disease, is a rare autoimmune disease in which antibodies attack the basement membrane in lung alveoli and renal glomeruli. Specifically, Goodpasture syndrome is caused by antibodies against type IV collagen. Patients typically present with bleeding from the lungs when coughing (hemotysis) and the kidney in the urine. Goodpasture's syndrome is a clinical diagnosis that is characterized by acute glomerulonephritis and pulmonary alveolar hemorrhage. The condition is very rare in children and is commonly associated with small vessel disease that is mediated by antineutrophil cytoplasmic autoantibodies (ANCAs) The Goodpasture syndrome is a rare autoimmune and life-threatening disease. It affects both kidneys and lungs. The Goodpasture syndrome was first identified by Dr. Ernest Goodpasture in 1919. It is also known as anti-GBM disease. In goodpasture syndrome, antibodies are produced against a specific region of collagen in kidneys and lungs Goodpasture syndrome, also known as anti-glomerular basement membrane disease, is a rare autoimmune disease. Patients with the syndrome experience a rapid progression to renal failure and death if the disease is not recognized and treated early. 1, - 3 First described by Ernest Goodpasture during the influenza pandemic of 1919, the syndrome has been extensively studied and has led to a. What is Goodpasture syndrome? Goodpasture's syndrome is an autoimmune disorder that usually involves both the lungs and the kidneys. Substances called anti-glomerular basement membrane antibodies are mistakenly released causing damage to the filtering system of the kidneys and air sacs in the lungs

Goodpasture's syndrome. ICD-9-CM 446.21 is a billable medical code that can be used to indicate a diagnosis on a reimbursement claim, however, 446.21 should only be used for claims with a date of service on or before September 30, 2015. For claims with a date of service on or after October 1, 2015, use an equivalent ICD-10-CM code (or codes) Goodpasture syndrome is a rare, debilitating autoimmune disease. An afflicted immune system creates antibodies that fight against the collagen found in the kidneys and lungs. Rather than being an 'invading' substance, collagen is a harmless and essential protein that's part of connective tissue Medical definition of Goodpasture's syndrome: an autoimmune disorder of unknown cause that is characterized by the presence of circulating antibodies in the blood which attack the basement membrane of the kidney's glomeruli and the lung's alveoli and that is marked initially by coughing, fatigue, difficulty in breathing, and hemoptysis progressing to glomerulonephritis and pulmonary hemorrhages An autoimmune disorder characterized by the production of autoantibodies against type IV collagen of the glomerular basement membrane of the kidney. In the majority of patients the immune reaction also extends to the alveolar capillary membrane of the lungs. The latter cases are referred to as Goodpasture Syndrome. Definition (CSP) combination. Goodpasture's syndrome is a rare disease that can affect the lungs and kidneys. Also called anti-glomerular basement antibody disease, it is an autoimmune disease—a condition in which the body's own defense system reacts against some part of the body itself. When the immune system is working normally, it creates antibodies to fight off germs

Goodpasture Syndrome Cedars-Sina

Goodpasture's syndrome is a rare disease. About 1 to 2% of all cases of rapidly progressive glomerulonephritis represent Goodpasture's syndrome. The incidence is about 1 in 2 million. Males are about seven times more prone to Goodpasture syndrome when compared to females. However, Goodpasture syndrome more commonly affects in adolescence Goodpasture's Syndrome is a rare illness that affects both the lungs and the kidneys and is also known as anti-glomerular basement antibody disease. It is classified as an autoimmune disease, a condition of the body where the defense system responds against some other part of the body, treating it as a threat

2 answers. Next. Depending on the severity of the attack and the effectiveness of the treatment, many patients achieve near full life expectancy. Posted Jul 6, 2017 by Paul 2200. It all depends when you find out you have it a how bad you are. Posted Oct 9, 2017 by Debbie 2000 Goodpasture syndrome. Goodpasture syndrome is a group of conditions that affects your kidneys and lungs. It causes your immune system to attack the tiny filters in your kidneys and the tissue in your lungs. Learn more about Goodpasture syndrome. Return to top. aHUS (atypical hemolytic uremic syndrome Lung - nontumor - Goodpasture syndrome. Lungs: heavy, focal necrosis of alveolar wall, fibrous thickening of septa with mild hyperplasia of alveolar lining cells, organization of blood in alveolar space and hemosiderin laden macrophages; linear deposits of immunoglobulin along basement membrane Kidney: focal proliferative to crescentic glomerulonephritis with linear deposits of immunoglobulin. These findings, in addition to the presence of pulmonary hemorrhage, are pathognomonic of Goodpasture syndrome. + + Hemoptysis ranging from blood-streaked sputum to massive hemorrhage is commonly the presenting feature. Patients may complain of dyspnea and cough. Pulmonary hemorrhage may be associated with severe hypoxemia and death Anti-Glomerular Basement Membrane Glomerulonephritis and Goodpasture Syndrome J. Charles Jennette Volker Nickeleit BACKGROUND INFORMATION Anti-GBM Disease In 1919, Ernest Goodpasture (1) reported an 18-year-old male patient who developed hemoptysis and acute renal failure after a flu-like illness. The patient died and at autopsy was found to have massive pulmonary hemorrhage and.

Goodpasture syndrome - American Kidney Fund (AKF

Goodpasture's syndrome/Anti-GBM/anti-TBM disease Overview Autoantibodies attack the lungs and kidneys and if left untreated this can quickly escalate to glomerulonephritis , kidney failure, or even death Goodpasture syndrome is a rare autoimmune disorder characterized by inflammation of the filtering structures (glomeruli) of the kidneys (glomerulonephritis) and excessive bleeding into the lungs (pulmonary hemorrhaging). Autoimmune syndromes occur when the body's natural defenses (antibodies) against invading or.. Medications for Goodpasture Syndrome Other names: Goodpasture's Syndrome. Also referred to as the more descriptive name, anti-glomerular basement membrane antibody disease. This autoimmune disease results from severe inflammation in the basement membranes of the glomerulus and the alveolus of the lung. Inflammation occurs due to the formation. To the Editor: Wegener's granulomatosis (WG) and Goodpasture's disease are unique etiologies of pulmonary-renal syndromes. Given the similarity in clinical presentation, differentiating these diseases at the bedside can be challenging. A 50-year-old woman was referred to the rheumatology clinic with a presumptive diagnosis of vasculitis. She presented with a 12-month history of recurrent. Goodpasture syndrome requires early and effective treatment if it is not to be fatal. The regimens in use have decreased the mortality rate from the original 96% to less than 20%

Goodpasture's syndrome: a clinical updat

Goodpasture syndrome. Idiopathic recurrent alveolar hemorrhage and rapidly progressive glomerulonephritis Patho: antiglomerular basement membrane antibodies Affects males between 30-40 years old. symptoms. hemoptysis dyspnea dry cough hypoxemia bilateral alveolar infiltrates Fe def anemi Goodpasture Syndrome (GS) is an autoimmune disease caused by the development of auto-antibodies against the Glomerular Basement Membrane (GBM). Linear deposit of immunoglobulins G on the GBM detected by immunofluorescence analysis of renal biopsies is a GS pathognomonic finding. GS is commonly monophasic and its incidence is 1.6 case per million per year Introduction. Goodpasture's syndrome is a rare clinical entity and is characterized by circulating autoantibodies which are principally directed against the glomerular/alveolar basement membrane. The etiology of Goodpasture's syndrome is still unknown. Lung involvement occurs as a result of lung injury and the exposure of new epitopes to the immune system Part I explores basic techniques to researching goodpasture syndrome (e.g. finding guidelines on diagnosis, treatments, and prognosis), followed by a number of topics, including information on how to get in touch with organizations, associations, or other patient networks dedicated to goodpasture syndrome If caught early, Goodpasture's Syndrome can be cured. Medications and blood treatments are used. However, if treatment is not started early enough, the kidneys can be permanently damaged, resulting in a lifelong need for dialysis. There are usually no long lasting effects to the lungs, but if Goodpasture's Syndrome is left untreated, bleeding.

Glomerulonephritis - Symptoms and causes - Mayo Clini

Goodpasture Syndrome - an overview ScienceDirect Topic

Goodpasture syndrome (GPS), also known as anti-glomerular basement membrane disease, is a disease that involves the kidneys and lungs. Symptom may include blood in the urine, protein in the urine, and coughing up blood. Shortness of breath, tiredness, and chest pain may also occur. Acute kidney failure may result.. It is believed to occur following an environmental trigger in people who are. Abbate M, Kalluri R, Corna D, et al. Experimental Goodpasture's syndrome in Wistar-Kyoto rats immunized with alpha3 chain of type IV collagen. Kidney Int 1998 ;54: 1550 - 1561 Crossre Patients with microscopic polyangiitis (MPA) are as a rule positive for MPO-ANCA, but cases with positive PR3-ANCA occur. Even patients with Churg-Strauss disease and Goodpasture syndrome may be positive for MPO-ANCA. Both in the case of GPA and of MPA an increase in the ANCA level may precede a relapse. The Capture method has proved superior. Goodpasture syndrome (60%): diffuse alveolar hemorrhage + acute glomerulonephritis Goodpasture disease: glomerulonephritis alone (30%,) pulmonary symptoms alone (10%,) Anti-GBM disease is most precise term for both entitie OVERVIEW. This page is dedicated to organizing various examples of standardized exam questions whose answer is Goodpasture syndrome.. While this may seem a odd practice, it is useful to see multiple examples of how Goodpasture syndrome will be characterized on standardized exams (namely the boards and the shelf exams). This page is not meant to be used as a traditional question bank (as all of.

Goodpasture syndrome Information Mount Sinai - New Yor

References in the ICD-10-CM Index to Diseases and Injuries applicable to the clinical term goodpasture's syndrome. Goodpasture's syndrome - M31.0 Hypersensitivity angiitis. Previous Term: Goodalls Disease. Next Term: Gopalans Syndrome Burning Feet Goodpasture syndrome is a rare disease that can involve quickly worsening kidney failure and lung disease. Some forms of the disease involve just the lung or the kidney. Causes. Goodpasture syndrome is an autoimmune disorder. It occurs when the immune system mistakenly attacks and destroys healthy body tissue Goodpasture syndrome (GPS), also known as anti-glomerular basement membrane disease, is a rare autoimmune disease in which antibodies attack the basement membrane in lungs and kidneys. This causes bleeding from the lungs and kidney failure.. Goodpasture syndrome may quickly result in permanent lung and kidney damage, often leading to death

Goodpasture syndrome - YouTubeAcute and chronic glomerulonephritis - YouTube

Common risk factors in the development of Goodpasture syndrome may be occupational, environmental, genetic, and viral. Recent studies suggest that infections such as viral or bacterial may play a role through molecular mimicry and increase the risk of developing Goodpasture syndrome. Other factors that may increase the risk of Goodpasture. Goodpasture's Syndrome Definition An uncommon and life-threatening hypersensitivity disorder believed to be an autoimmune process related to antibody formation in the body. Goodpasture's syndrome is characterized by renal (kidney) disease and lung hemorrhage. Description The disorder is characterized by autoimmune reaction which deposits of antibodies. Goodpasture's syndrome is a rare disease. Even though the classical presentation is that of rapidly progressive glomerulonephritis pulmonary hemorrhage and anti-GBM antibodies in the circulation and kidneys, in rare cases it can present with repeated pulmonary hemorrhage and minor urinary abnormalities

Goodpasture Syndrome Treatment & Management: Approach

Goodpasture Syndrome. Definition: Goodpasture syndrome (GP S) is a rare disease that can involve quickly worsening kidney failure and lung disease. It is also known as anti-glomerular basement membrane disease. It is thought to attack the alpha-3 subunit of type IV collagen, which has therefore been referred to as Goodpasture's antigen Anti-GBM disease, and in particular Goodpasture syndrome, if untreated or if treated with delay, has a fulminant course. In a recent survey, 6 months after a sample with a positive anti-GBM test was drawn, 35% of the patients had died, 40% were on renal replacement therapy and only 25% were alive with a functioning kidney Goodpasture syndrome. hypersensitivity reaction type II disease that is characterized by glomerulonephritis located in kidney and hemorrhaging located in lung. Upload media. Wikipedia. Instance of. disease, designated intractable/rare diseases. Subclass of. secondary glomerular disease

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